SYSADOA (SYmptomatic Slow-Acting Drugs in Osteoarthritis

Glucosamina
MEDLINE
Google
Scirus

Diacereína
MEDLINE
Google
Scirus
 

Condroitín Sulfato
MEDLINE
Google
Scirus
 

Hialuronico
MEDLINE
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Scirus


 



Artrosis en colorines
 (SYmptomatic Slow-Acting Drugs in Osteoarthritis) es un termino acuñado para albergar una serie de sustancias y medicamentos que en teoría modifican la progresión de la osteoartrosis y de los que se ha proclamado un efecto condroprotector. Lo único que se ha podido demostrar hasta el momento es un efecto sobre los síntomas con un comienzo de actuación lento, de ahí su nombre.


Un poco sobre terminología

"In 1994, the adjective “symptomatic” was considered mandatory for these drugs, because excessive claims regarding their “chondroprotective” (now “structure modulating”) virtues were at that time often alleged without evidence. However, SYSADOAs being considered as possible disease modifying drugs were in a position to be tested as potential structure modulators.
To demonstrate such an effect, long-term (2 to 3 years) randomized controlled trials were undertaken. Whereas their clinical effect on pain and function is consistently showed as positive in the mid-term trials, this symptomatic benefit is not confirmed in the long-term structure modulating studies"

De Lequesne MC. Symptomatic slow-acting drugs in osteoarthritis: Discrepancy in results between mid-term and long-term trials. En: http://www.rheuma21st.com/archives/cutting_edge_osteoarthritis_lesquense.html


La cara y la cruz de la información sobre SYSADOA

La Cara

De EULAR recommendations 2003: an evidence-based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

La Cruz

De Castaño Carou et al. Artrosis Guías Clínicas 2003; 3 (18) en http://www.fisterra.com/guias2/artrosis.asp


 

Para saber más:  
Boletín INFAC (PDF) Rheuma 21 Cutting Edge Reports
Glucosamine and chondroitin for knee OA  
NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT Glucosamine for osteoarthritis of the knee
Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial Is it safe for people with diabetes to take glucosamine? (PDF)
   

Guías de Práctica Clínica y

 Revisiones
Recommendations for the Medical Management of Osteoarthrits of the Hip and Knee. 2000 AAOS clinical practice guideline on osteoarthritis of the knee. 2003 Algoritmo (PDF)
Diagnosis and Treatment of Degenerative Joint Disease of the Knee, Adult ICS 2003 Gudelines Clinical Care Knee pain or swelling: acute or chronic. 2002 PDF
Guía Clínica de Artrosis- Fisterra Medical management of osteoarthritis of the knee and hip joints (MJA)
EULAR recommendations 2003: an evidence-based approach to the management of knee osteoarthritis:  Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)