| Efficacy of posaconazole in a murine disseminated infection by Candida tropicalis. |
| Marine M., Pastor F.J., Guarro J., |
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| Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenc 21, 43201, Reus, Spain. |
| We evaluated the efficacy of posaconazole against Candida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by C. tropicalis. |
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